Research area
- The scientific direction of laboratory is a research of chemical transformation principles of cellulose, its derivatives and hydrophilic synthetic polymers; an establishment of correlation between chemical, supramolecular structure of polymers and their reaction ability, and properties of obtained products.
Development of the new approach of molecular design of macromolecular systems on the basis of cellulose and synthetic polymers, with the purpose of creation of products with desired medical and biological properties.
Important results
- The regularity of carboxymethylation reaction of cellulose of a various origin (wood, cotton cellulose, linter cellulose) is established. An opportunity of carboxymethylcellulose obtaining with the given molecular parameters (a polymerization degree from 30 to 550 and a substitution degree on -СООН groups from 0,1 to 1,0, on an arrangement -СООН groups inside a link of a macromolecule (С2, С3, С6) is shown.
For the first time "abnormal regularity" of copolymerization reactions of active comonomers on example of copolymerization pairs of monomers established: methacryloyl chloride - vinylpyrrolidon, methacryloyl chloride - metacrylic acid, etc. The ways of regulation of reaction of abnormal copolymerization are established.
For the first time the chemical transformation of carboxymethylcellulose (CMC) is established, i.e. reaction of chemical cross-linking of CMC with bifunctional substances (formaldehyde, urea-dimethylolethylen, urea-dimethyloldiethylen, etc.) in the heterogeneous and homogeneous medium, reaction of nitration, reaction of neutralization with the various bases, reaction with complex salts of polyvalent metals are found.
Research of medical and biological properties of products of transformation CMC, copolymers on the basis of synthetic polymers establishes their biocompatibility, harmlessness for an alive organism and a principal opportunity of development on their basis of polymeric medical products, surgical products.
The opportunity of creation of resorptional materials in living organism on a basis of CMC for the first time is shown and established mechanisms of process absorption.
Practical application of results
- Applied research of laboratory is devoted on purposeful synthesis of medical and biological polymers and to creation of new medical polymeric preparations, surgical products, diagnostic and other auxiliary means for applied medicine. Original preparations and surgical products for the first time are developed and received sanctions for application in medical practice:
- resorptional surgical string "Caselon" on CMC basis for recovering wounds of internal bodies;
- a resorptional surgical string "Biolon" on the basis of a polyether and polyamide for recovering wounds;
- draining sorbent "Gelecel" on a basis of chemically tailored CMC for treatment of purulent wounds;
- gel "Polijel" on a basis of low concentration solution CMC, in quality to the contact medium for ultrasonic diagnostics;
- an embolus polymeric material on the basis of copolymers methacrylic acids for endovoscular surgeries;
- resorptional styptic napkin "Gemocel" on CMC basis for a stoppage of bleeding in the closed wounds;
- an antianginal preparation "Nitrocel in a tablet" produced on a basis of nitroether of CMC for cardiology;
- a fluffer on a basis CMC for tabulating medical products;
- an adhesive powder "Biodent" for fixing demountable dental artificial limbs for stomatology;
- manufacture of these preparations is assimilated on an experimental department of Institute and, presently, they are realized in chemical networks of the country.
Plans for future
- Purposeful synthesis of cellulose sulfate and its derivatives, creation of antiviral, antibacterial substances on their basis.
Research of chemical aspects of creation of netted macromolecular systems on the basis of cellulose and its derivatives for application in medicine, biology and an agriculture.
Creation of gel systems for development of highly effective, soft medicinal forms.
Development of new medical and biologic polymers: strings on the basis of silk, adhesive powders for stomatology, medical products for cardiology, antitubercular polymeric preparations, gel medicines for wound and burns.
Scientific links
- Dept. Materials & Life Science, Graduate School of Science & Technology, Kumamoto University, Japan.
- Hamburg University.
- Jena University.
- North London University.
Research staff
- Hudayberdiev M., senior researcher, D.S. (2000)
- Gulyamov T.G., senior researcher, Ph.D. (1993)
- Atazhanov A.A., senior researcher, Ph.D. (1995)
- Muradov E.A., senior researcher, Ph.D. (1999)
- Hvan A.M., senior researcher, Ph.D. (1986)
- Karchagina G.K., junior researcher
- Filatova A.V., junior researcher, Ph.D. (2002)
- Madjidova V., junior researcher, Ph.D. (1998)
- Sultanova B.M., junior researcher
- Normakhamatov N.S., junior researcher
- Akramov K., junior researcher
- Haytmetov R.M., junior researcher
- Shamuratov S.A., post-graduated student
- Juraboev J., post-graduated student
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Cellulose
Na-nitrocarboxymethylcellulose
Na-trisulfatcellulose
Resorptional surgical
string "Caselon"
Non-resorptional surgical
string of "Biolon"
Draining sorbent
"Gelecel" and "Embol"
Gels "Polijel" and "Cardiogel"
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