Research area
- Structural investigation of crystalline inclusion compounds (host-guest complexes or clathrates) by X-ray diffraction method. Studying objects are clathrates of gossypol and its derivatives, cyclotriveratrylene, cyclodextrins, calix-arenes, crown-ethers and etc.
Important results
- It is discovered an unique host ability of biologically active natural compound gossypol.
It is established a great tendency of clathrates of versatile host compounds to pseudopolymorphic behavior and formulated new rule correlating structures and formation conditions of individual modifications: the high crystallization temperature of the clathrate modification the more close is space occupied by guest molecules.
Practical application of results
Topological control of pseudopolymorphic clathrates.
An effective solid-state reaction of asymmetric monoaminoderivatives on the matrix of gossypol organic zeolite.
Biopharmaceutical optimization of biologically active host compounds.
Plans for future
- Checking of the formulated rule on the example of other versatile hosts.
Isolation of other gossypol-related pigments from cotton seeds and study of their biological and host properties.
Working out of methodology for preparation of nanoporous materials by decomposition of unstable clathrates.
Scientific links
- Technische Universitat (Freiberg, Germany).
- University of Bern (Berne, Switzerland).
- Ohio State University (Columbus, USA).
- Universite Claude Bernard (Lyon, France).
- University of Nottingham (Nottingham, England).
- A.Miskevich University (Poznan, Poland).
International grants
- Rockefeller Foundation (USA, 1990)
- ISF (USA, 1994)
- INTAS (European Community, 2000)
- SCOPES (Switzerland, 2001)
- CRDF (USA, 2002)
Research staff
- Talipov S.A., senior researcher, Ph.D. (1988)
- Izotova L.Yu., senior researcher, Ph.D. (1999)
- Machkamov К.К., junior researcher, Ph.D. (2000)
- Tilyakov Z.G., junior researcher, Ph.D. (2001)
- Ashurov J.M., junior researcher
- Tojimukhamedov P.Kh., master degree
- Tilyabaev К.Z., student
|
|
The first endocyclic solvate
of cyclotriveratrylene is obtained on example of clathrate with acetone at 40 C
Gossypol complex with pyrazinе may serve as individual host
It is prepared the first nanoporous compound with channel diameter more then 10A (totally organic zeolite) - sesquihydrate of 1,1'-binaphtil-2,2'-dicarboxylic acid
Data collection are performed
on X-Ray diffractometer
"Syntex-P21" (USA)
|
Team leader:
