Research area
- The studying of enzyme resistance mechanism of cotton pests and making the selective insect-acaricides and synergists. The observing subjects are enzymes from esterase's complex of cotton pests. The investigation of the complex-forming and extractive properties for the phosphor organic models.
Important results
- Conditions for synthesis of large amounts of phosphor acids derivates have been developed.
It is elaborated a method of asymmetric synthesis of phosphorus and carbamine ethers with alkaloids and nitrogenous heterocycles.
By using chemical substances, the exclusive knowledge about structure and topography of hydrophobic organization with catalytic esterase center for the mammals and arthropods and also their localization hydrolyze dynamic activity into ontogenesis have been obtained.
Practical application of results
- The synthetic substrates and inhibitors of esterase are used like chemical instruments especially for identification and putting classify belonging of esterase for different animals and their standardization.
The effective synergists of mezurole, rogore and dorzane against Agrotis segetum and carbophose against Tetranychus urticae Koch have been produced.
The effective Au, Ag, Pt, Os extragents have been obtained.
Plans for future
- To offer the model of enzymes process for resistance development.
Obtaining of selective insecticides from the esterase's inhibitors.
The combination of extragentes on the polymer base.
Scientific links
- The Institute of element-organic substances (Moscow).
- The Institute of evolution and physiology and biochemistry of S.Petersburg.
- The Institute of organic and biological physics (Estonia).
- The Institute of organic synthesis and carbochemistry (Kazakhstan).
Research staff
- Babaev B.N., senior researcher, Ph.D. (1990)
- Abdullaeva L.K., senior researcher
- Juraev Z.U., engineer
- Mirackmedov N.Sh., engineer
- Allaeva L.Ph., post-graduate student
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Molecular and conformational structure of o-isobutyl-o-1-N-b anabasine (methyl-thyophosphonate isopropyl)
Rodentia cotton pests
Scheme of enzyme's interaction
with substrate
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