TEAM OF RESEARCH OF PROTEIN AND PEPTIDE BIOREGULATORS AND BIOPROTECTORS OF COTTON PLANTS		Team leader:   Doctor of Sciences   Veshkurova O.N.
Research area Structurally functional characterization of bioregulators of an animal and vegetative origin.    Important results Cotton receptor proteins specific to ethylene, cytokinines, auxines have been isolated. Their structurally and functional parameters are studied. The method of competitive-receptor probe for pesticides analysis is developed. The molecular mechanism of action of defoliants - phenylheterylurea derivatives is investigated. The energetic characteristics of intermolecular complexes of a fragment of the active center of cytokinine receptor with some herbicides and defoliants are calculated by quantum-chemical method. Fungi toxic peptides from cotton and ambary seeds are isolated    Practical application of results The biosensor for analysis of triazine and phenylurea pesticides on a basis of cotton cytokinine receptor is developed.    Plans for future Isolation and structurally and functional characterization of biocide peptides from Malvaceae seeds - effective against phytopathogene and pest insects with the purpose of creation of generically modified insect and fungiresistant cotton cultivars. Development of test - system for selection pathogen resistant to new cotton cultivars.    Scientific links Moscow State University, Department of enzymology (Moscow, Russia). Cotton Pathology Research Unit, College Station (Texas, USA).    International grants STCU Uz 001 "Investigation of Functionality Significant Proteins of Cotton Seeds and Development of Highly Effective Technologies of the Production of Provender on the Basis of Cotton Seed Oil Cake" 1999-2000. STCU Uz 75 "Development of biosensors for pesticides determination in environmental in cotton-cultivated countries" 2002-2003. STCU P115 "Characterization of Phytoalexins from the Malvaceae in Uzbekistan" 2003-2005.    The scientific personnel Veshkurova O.N., Doctor of Sciences. Arzanova I.A., senior researcher, PhD (1996). Sultanova E.M., senior researcher, PhD (1993). Uzbekov V.V., senior researcher, PhD (2002). Maksimov V.V., junior researcher. Pshenichnov E.A., post graduate student.				Model of an intermolecular complex of the active center of CBP with triazine derivatives Dr R.Stipanovic from USDA with senior research worker V.Uzbekov is analyzing sum of phytoalexins by HPLC Electrophoresis of fungi toxic peptides Gel filtration of peptides of Hibiscus cannabinus